Skip to content
  • Argentina
  • Brazil
  • Canada
  • Chile
  • Colombia
  • Europe
  • France
  • Germany
  • India
  • Italy
  • Japan
  • Korea
  • Mexico
  • Perú
  • Russia
  • Spain
  • Taiwan
  • The Middle East
  • Turkey
  • United Kingdom
  • United States
  • Vietnam
  • USA
  • New Clinic Portal
    • 13055014948
  • Request Information
IGENOMIX – With science on your sideIGENOMIX – With science on your side
  • We guide you
    • Fertility
  • Reproductive Health
    • Specialists
      • ERA
      • EndomeTRIO
      • EMMA
      • ALICE
      • PGT-A + ERA Synchrony
      • PGT-A
      • Family Balancing
      • EMBRACE
      • PGT-M
      • POC
      • SAT
    • Patients
      • ERA
      • EndomeTRIO
      • EMMA
      • ALICE
      • PGT-A + ERA Synchrony
      • PGT-A
      • Family Balancing
      • EMBRACE
      • PGT-M
      • POC
      • SAT
  • Kit Request
  • Genetic Counseling
  • Education
    • Videos
    • Webinars
  • ACADEMY
  • About us
    • Igenomix Research
    • About Igenomix
  • Blog
    • Blog
    • Patient Stories
  • Diagnostics
Genetic Solutions > ALICE

ALICE Analysis of Infectious Chronic Endometritis

ALICE detects the bacteria causing chronic endometritis to improve your patient’s reproductive prognosis.

  • Technical Overview
  • Documentation
  • Scientific evidence
  • I’m not a health specialist

20% of infertility is caused by the endometrial factor.

Chronic endometritis affects up to 30% of infertile patients.

In cases of RIF or recurrent pregnancy loss, chronic endometritis can rise to 66%

Are you interested?

Request information Or email us at infousa@igenomix.com
Overview
  • ALICE
  • Benefits
  • Indications

What is ALICE test?

  • ALICE is a test that detects pathogenic bacteria causing chronic endometritis.
  • Chronic endometritis is linked to implantation failure and recurrent miscarriage.
  • In cases of repeated implantation failure or recurrent pregnancy loss, chronic endometritis can rise to 66%.

What is the procedure?

chronic endometritis
  • ALICE can be performed on a small piece of an endometrial biopsy.

Why use ALICE?

  • ALICE is a diagnostic test to detect and quantify the most common pathogenic bacteria causing chronic endometritis.
  • ALICE uses RT-PCR technology to provide microbiome information in endometrial tissue by analysing the abundance of specific bacteria causing chronic endometritis.
  • This technology allows the identification of culturable and nonculturable endometrial pathogens associated with chronic endometritis.
  • Microbiology counselling is available for health specialists.

Who should use ALICE?

  • ALICE can be beneficial for any patient wishing to conceive, by assessing the microbiological environment that the embryo will encounter at implantation.
  • ALICE may also be beneficial for patients with a history of recurrent pregnancy loss or recurrent implantation failure because chronic endometritis has been linked to these events.

Test limitations:

  • This test is not able to detect resistance to antibiotics.
  • ALICE only detects the presence of pathogens associated with Chronic Endometritis. A negative result doesn’t rule out  the presence of other endometrial pathogens.
Documentation & Resources
  • ALICE Specialists' documents

Brochure

Download

ALICE Manual

Download

Antibiotic Dosage Recommendations

Download

Acceptable OCPs for EMMA and ALICE Testing

Download
Scientific evidence

Relevant related studies:

Endometrial microbiota composition is associated with reproductive outcome in infertile patients

Inmaculada Moreno, Iolanda Garcia-Grau,  David Perez-Villaroya,  Marta Gonzalez-Monfort,  Mustafa Bahçeci, Marcelo J. Barrionuevo, Sagiri Taguchi,  Elena Puente,  Michael Dimattina, Mei Wei Lim, Georgina Meneghini, Mira Aubuchon, Mark Leondires, Alexandra Izquierdo, Martina Perez-Olgiati, Alejandro Chavez, Ken Seethram, Davide Bau, Carlos Gomez, Diana Valbuena, Felipe Vilella & Carlos Simon

January 04, 2022

Structure, function and diversity of the healthy human microbiome.

Human Microbiome Project Consortium.

Nature 2012; 486:207–14.

Evidence that the endometrial microbiota has an effect on implantation success or failure.

Moreno I, Codoñer FM, Vilella F, Valbuena D, Martinez-Blanch JF, Jimenez-Almazan J, Alonso R, Alama P, Remohi J, Pellicer A, Ramon D, Simon C.

Am J Obstet Gynecol. 2016; 215:684-703. 

 The diagnosis of chronic endometritis in infertile asymptomatic women: a comparative study of histology, microbial cultures, hysteroscopy, and molecular microbiology.

Moreno I, Cicinelli E, Garcia-Grau I, Gonzalez M, Bau D, Vilella F, De Ziegler D, Resta L, Valbuena D, Simon C.

Am J Obstet Gynecol. 2018, DOI: 10.1016/j.ajog.2018.02.012. 

If you´re a little lost with this technical information...

Can we help you?

I’m not a health specialist

Igenomix and fertility

We work to make a world in which infertility is no longer an impossible barrier. Together with clinics and fertility doctors worldwide we investigate human reproduction to change the lives of couples who are trying to conceive.

Other services

ERA

Evaluates the endometrial receptivity

More information

EMMA

Evaluates the endometrium at the microbiological level

More information

EndomeTRIO

A new dimension of endometrial health to improve your reproductive prognosis More information

Igenomix is in the media

Igenomix is not affiliated with any news outlet or publication identified above. News coverage does not constitute an endorsement of Igenomix or its products.

WE GUIDE YOU

Fertility
COVID-19 basic Q&A

OUR SERVICES

For Health Specialists
For Patients

ABOUT US

About Igenomix
Contact
Press and news
Work with us
Quality

FOLLOW IGENOMIX

Blog: Road to fertility

 

*CAP accreditation applies to the LA lab.

 

  +1 (305) 501-4948 
  Email us
  • Argentina
  • Brazil
  • Canada
  • Chile
  • Colombia
  • Europe
  • France
  • Germany
  • India
  • Italy
  • Japan
  • Korea
  • Mexico
  • Perú
  • Russia
  • Spain
  • Taiwan
  • The Middle East
  • Turkey
  • United Kingdom
  • United States
  • Vietnam
Language

[2019] © Igenomix Privacy policy & cookies policy Quality policy Terms & conditions User Feedback

Open this in UX Builder to add and edit content

Request Information

Copyright 2023 © UX Themes
  • We guide you
    • Fertility
  • Reproductive Health
    • Specialists
      • ERA
      • EndomeTRIO
      • EMMA
      • ALICE
      • PGT-A + ERA Synchrony
      • PGT-A
      • Family Balancing
      • EMBRACE
      • PGT-M
      • POC
      • SAT
    • Patients
      • ERA
      • EndomeTRIO
      • EMMA
      • ALICE
      • PGT-A + ERA Synchrony
      • PGT-A
      • Family Balancing
      • EMBRACE
      • PGT-M
      • POC
      • SAT
  • Kit Request
  • Genetic Counseling
  • Education
    • Videos
    • Webinars
  • ACADEMY
  • About us
    • Igenomix Research
    • About Igenomix
  • Blog
    • Blog
    • Patient Stories
  • Diagnostics
  • USA
  • New Clinic Portal
Free Call Contact us