ALICE Analysis of Infectious Chronic Endometritis

ALICE detects the bacteria causing chronic endometritis to improve your patient’s reproductive prognosis.

Overview

ALICE
Benefits
Indications

What is ALICE test?

ALICE is a test that detects pathogenic bacteria and recommends adequate treatment.
Pathogenic bacteria cause chronic endometritis, which is linked to implantation failure and recurrent miscarriage.
In cases of repeated implantation failure or recurrent pregnancy loss, chronic endometritis can rise to 66%.

What is the procedure?

ALICE can be performed on a small piece of an endometrial biopsy.

Why use ALICE?

ALICE is a diagnostic test to detect and quantify the most common pathogenic bacteria causing chronic endometritis, recommending appropriate antibiotic and probiotic treatment
ALICE uses the latest Next Generation Sequencing (NGS) technology to provide microbiome information in endometrial tissue by analysing the abundance of specific bacteria causing chronic endometritis
Using NGS allows the identification of culturable and nonculturable endometrial pathogens associated with chronic endometritis
If the ALICE test is positive, the report will focus on the detection of the specific bacteria causing the condition
A recommendation of the most appropriate antibiotic is made based on the bacteria detected.
Microbiology counselling is available

Who should use ALICE?

ALICE can be beneficial for any patient wishing to conceive, by assessing the microbiological environment that the embryo will encounter at implantation.
ALICE may also be beneficial for patients with a history of recurrent pregnancy loss or recurrent implantation failure because chronic endometritis has been linked to these events.

Test limitations:

This test is not able to detect resistance to antibiotics.
ALICE only detects the presence of pathogens associated with Chronic Endometritis. A negative result doesn’t rule out the presence of other endometrial pathogens.
This test is not 100% accurate at determining the bacterial species.

Documentation & Resources

ALICE Specialists' documents

Relevant related studies:

Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature 2012; 486:207–14.

Moreno I, Codoñer FM, Vilella F, Valbuena D, Martinez-Blanch JF, Jimenez-Almazan J, Alonso R, Alama P, Remohi J, Pellicer A, Ramon D, Simon C. Evidence that the endometrial microbiota has an effect on implantation success or failure. Am J Obstet Gynecol. 2016; 215:684-703.

Moreno I, Cicinelli E, Garcia-Grau I, Gonzalez M, Bau D, Vilella F, De Ziegler D, Resta L, Valbuena D, Simon C. The diagnosis of chronic endometritis in infertile asymptomatic women: a comparative study of histology, microbial cultures, hysteroscopy, and molecular microbiology. Am J Obstet Gynecol. 2018, DOI: 10.1016/j.ajog.2018.02.012.

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20% of infertility is caused by the endometrial factor.

Chronic endometritis affects up to 30% of infertile patients.

In cases of RIF or recurrent pregnancy loss, chronic endometritis can rise to 66%

Are you interested?

What is ALICE test?

What is the procedure?

Why use ALICE?

Who should use ALICE?

Test limitations:

Clinical Sheets

EndomeTRIO Manual

Brochure

Relevant related studies:

Can we help you?

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