Genetic Solutions > ALICE

ALICE Analysis of Infectious Chronic Endometritis

ALICE detects the bacteria causing chronic endometritis to improve your patient’s reproductive prognosis.

Overview

ALICE
Benefits
Indications

What is ALICE test?

ALICE is a test that detects pathogenic bacteria causing chronic endometritis.
Pathogenic bacteria cause chronic endometritis, which is linked to implantation failure and recurrent miscarriage.
In cases of repeated implantation failure or recurrent pregnancy loss, chronic endometritis can rise to 66%.

What is the procedure?

ALICE can be performed on a small piece of an endometrial biopsy.

Why use ALICE?

ALICE is a diagnostic test to detect and quantify the most common pathogenic bacteria causing chronic endometritis.
ALICE uses RT-PCR technology to provide microbiome information in endometrial tissue by analysing the abundance of specific bacteria causing chronic endometritis.
This technology allows the identification of culturable and nonculturable endometrial pathogens associated with chronic endometritis.
Microbiology counselling is available for health specialists.

Who should use ALICE?

ALICE can be beneficial for any patient wishing to conceive, by assessing the microbiological environment that the embryo will encounter at implantation.
ALICE may also be beneficial for patients with a history of recurrent pregnancy loss or recurrent implantation failure because chronic endometritis has been linked to these events.

Test limitations:

This test is not able to detect resistance to antibiotics.
ALICE only detects the presence of pathogens associated with Chronic Endometritis. A negative result doesn’t rule out the presence of other endometrial pathogens.

Documentation & Resources

ALICE Specialists' documents

Brochure

Download

ALICE Manual

Download

Antibiotic Dosage Recommendations

Download

Acceptable OCPs for EMMA and ALICE Testing

Download

Scientific evidence

Relevant related studies:

Endometrial microbiota composition is associated with reproductive outcome in infertile patients

Inmaculada Moreno, Iolanda Garcia-Grau, David Perez-Villaroya, Marta Gonzalez-Monfort, Mustafa Bahçeci, Marcelo J. Barrionuevo, Sagiri Taguchi, Elena Puente, Michael Dimattina, Mei Wei Lim, Georgina Meneghini, Mira Aubuchon, Mark Leondires, Alexandra Izquierdo, Martina Perez-Olgiati, Alejandro Chavez, Ken Seethram, Davide Bau, Carlos Gomez, Diana Valbuena, Felipe Vilella & Carlos Simon

January 04, 2022

Structure, function and diversity of the healthy human microbiome.

Human Microbiome Project Consortium.

Nature 2012; 486:207–14.

Evidence that the endometrial microbiota has an effect on implantation success or failure.

Moreno I, Codoñer FM, Vilella F, Valbuena D, Martinez-Blanch JF, Jimenez-Almazan J, Alonso R, Alama P, Remohi J, Pellicer A, Ramon D, Simon C.

Am J Obstet Gynecol. 2016; 215:684-703.

The diagnosis of chronic endometritis in infertile asymptomatic women: a comparative study of histology, microbial cultures, hysteroscopy, and molecular microbiology.

Moreno I, Cicinelli E, Garcia-Grau I, Gonzalez M, Bau D, Vilella F, De Ziegler D, Resta L, Valbuena D, Simon C.

Am J Obstet Gynecol. 2018, DOI: 10.1016/j.ajog.2018.02.012.

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20% of infertility is caused by the endometrial factor.

Chronic endometritis affects up to 30% of infertile patients.

In cases of RIF or recurrent pregnancy loss, chronic endometritis can rise to 66%

Are you interested?

What is ALICE test?

What is the procedure?

Why use ALICE?

Who should use ALICE?

Test limitations:

Brochure

ALICE Manual

Antibiotic Dosage Recommendations

Acceptable OCPs for EMMA and ALICE Testing

Relevant related studies:

Can we help you?

Igenomix and fertility

ERA

EMMA

EndomeTRIO