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Genetic Solutions > ALICE

ALICE Analysis of Infectious Chronic Endometritis

ALICE detects the bacteria causing chronic endometritis to improve your patient’s reproductive prognosis.

  • Technical Overview
  • Documentation
  • Scientific evidence
  • I’m not a health specialist

20% of infertility is caused by the endometrial factor.

Chronic endometritis affects up to 30% of infertile patients.

In cases of RIF or recurrent pregnancy loss, chronic endometritis can rise to 66%

Are you interested?

Request information Or email us at infousa@igenomix.com
Overview
  • ALICE
  • Benefits
  • Indications

What is ALICE test?

  • ALICE is a test that detects pathogenic bacteria and recommends adequate treatment.
  • Pathogenic bacteria cause chronic endometritis, which is linked to implantation failure and recurrent miscarriage.
  • In cases of repeated implantation failure or recurrent pregnancy loss, chronic endometritis can rise to 66%.

What is the procedure?

endometritis
  • ALICE can be performed on a small piece of an endometrial biopsy.

Why use ALICE?

  • ALICE is a diagnostic test to detect and quantify the most common pathogenic bacteria causing chronic endometritis, recommending appropriate antibiotic and probiotic treatment
  • ALICE uses the latest Next Generation Sequencing (NGS) technology to provide microbiome information in endometrial tissue by analysing the abundance of specific bacteria causing chronic endometritis
  • Using NGS allows the identification of culturable and nonculturable endometrial pathogens associated with chronic endometritis
  • If the ALICE test is positive, the report will focus on the detection of the specific bacteria causing the condition
  • A recommendation of the most appropriate antibiotic is made based on the bacteria detected.
  • Microbiology counselling is available

Who should use ALICE?

  • ALICE can be beneficial for any patient wishing to conceive, by assessing the microbiological environment that the embryo will encounter at implantation.
  • ALICE may also be beneficial for patients with a history of recurrent pregnancy loss or recurrent implantation failure because chronic endometritis has been linked to these events.

Test limitations:

  • This test is not able to detect resistance to antibiotics.
  • ALICE only detects the presence of pathogens associated with Chronic Endometritis. A negative result doesn’t rule out  the presence of other endometrial pathogens.
  • This test is not 100% accurate at determining the bacterial species.
Documentation & Resources
  • ALICE Specialists' documents

Clinical Sheets

Download

EndomeTRIO Manual

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EndomeTRIO Manual

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Brochure

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Scientific evidence

Relevant related studies:

Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature 2012; 486:207–14.

Moreno I, Codoñer FM, Vilella F, Valbuena D, Martinez-Blanch JF, Jimenez-Almazan J, Alonso R, Alama P, Remohi J, Pellicer A, Ramon D, Simon C. Evidence that the endometrial microbiota has an effect on implantation success or failure. Am J Obstet Gynecol. 2016; 215:684-703. 

Moreno I, Cicinelli E, Garcia-Grau I, Gonzalez M, Bau D, Vilella F, De Ziegler D, Resta L, Valbuena D, Simon C. The diagnosis of chronic endometritis in infertile asymptomatic women: a comparative study of histology, microbial cultures, hysteroscopy, and molecular microbiology. Am J Obstet Gynecol. 2018, DOI: 10.1016/j.ajog.2018.02.012. 

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  • Education
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