The Endometrial Receptivity Analysis (ERA), developed and patented by Igenomix (PCT/ ES2009/000386), is a test designed to evaluate endometrial receptivity.
ERA® is the first diagnostic test that determines each woman’s unique personalized embryo transfer timing, therefore synchronizing the embryo transfer with the individualized window of implantation.
ERA RCT CONCLUSIONS
Our randomised study shows that customising embryo transfer to the day of the cycle on which the patient is receptive has better results than transferring on a standard day.
What is the procedure?
The ERA utilizes RNA obtained from an endometrial tissue sample. The RNA analyzed and then classified by our ERA predictor as receptive or non-receptive, depending on the expression profile of the RNA.
If the endometrium is non-receptive, the test enables us to find a personalized window of implantation for each patient in the majority of cases.
Why use ERA test?
Our randomized study* confirms that personalizing embryo transfer according to the day of the cycle in which the patient is receptive achieves better results than transferring on a standard day.
56.2% live birth rate in the first embryo transfer.*
ERA maximizes your patient’s chances of pregnancy.
This molecular diagnostic tool uses NGS to analyze the expression level of 248 genes related to the status of endometrial receptivity.
ERA is backed by ERA is backed by 25 publications; 16 from Igenomix and 9 external publications.
Proprietary algorithm based on machine learning that minimizes the need for second biopsy (90% of cases).
Allows clinicians to identify transition phases with 12 hours shifts.
Who should use ERA test?
ERA test is indicated for patients with implantation failure of endometrial origin.
Clinical studies, at different stages of development, are exploring the indication for ERA in first-visit IVF patients.
When to perform ERA to your Patient?
When is a second biopsy needed?
90 % of cases don’t need a second biopsy. The second biopsy is only required under two circumstances:
Patients with a “Pre-receptive” result needing 2 more days with progesterone.
Patients with a “Post-receptive” result.
Test limitations
*Simón et al. A 5-year Multicenter Randomized Controlled Trial of In Vitro Fertilization with Personalized Blastocyst Transfer versus Frozen or Fresh Transfer. Reproductive BioMedicine Online (2020). DOI:10.1016/j.rbmo.2020.06.002
**In patients with recurrent implantation failure (RIF). Ruiz-Alonso et al., The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure. Fertility and Sterility, 2013;100(3):818-24. 10.1016/j.fertnstert.2013.05.004.
*Simón et al. A 5-year Multicenter Randomized Controlled Trial of In Vitro Fertilization with Personalized Blastocyst Transfer versus Frozen or Fresh Transfer. Reproductive BioMedicine Online (2020). DOI:10.1016/j.rbmo.2020.06.002
**In patients with recurrent implantation failure (RIF). Ruiz-Alonso et al., The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure. Fertility and Sterility, 2013;100(3):818-24. 10.1016/j.fertnstert.2013.05.004.
Tan J, Kan A, Hitkari J, Taylor B, Tallon N, Warraich G, Yuzpe A, Nakhuda G.
J Assist Reprod Genet. 2018 Jan 11. doi: 10.1007/s10815-017-1112-2.
PMID:29327111
The Reproductive Outcomes for the Infertile Patients with Recurrent Implantation Failures May Be Improved by Endometrial Receptivity Array Test.
Ota, T., Funabiki, M., Tada, Y., Karita, M., Hayashi, T., Maeda, K. et al.
Journal of Medical Cases. 2019; 10(5), 138-140. doi: https://doi.org/10.14740/jmc3282
Why results of endometrial receptivity assay testing should not be discounted in recurrent implantation failure? Simrandeep K., Padmaja N. The Onco Fertility Journal. 2019; 2(1): 46-49.
Personalized Embryo Transfer Helps in Improving In vitro Fertilization/ICSI Outcomes in Patients with Recurrent Implantation Failure.
Patel JA, Patel AJ, Banker JM, Shah SI, Banker MR. J Hum Reprod Sci. 2019; 12(1):59-66. doi: 10.4103/jhrs.JHRS_74_18.
Endometrial Receptivity Analysis – a tool to increase an implantation rate in assisted reproduction.
We work to make a world in which infertility is no longer an impossible barrier. Together with clinics and fertility doctors worldwide we investigate human reproduction to change the lives of couples who are trying to conceive.
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A new dimension of endometrial health to improve your reproductive prognosis
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Igenomix is not affiliated with any news outlet or publication identified above. News coverage does not constitute an endorsement of Igenomix or its products.
