SAT Sperm aneuploidy test

SAT
Benefits
Indications

What is SAT test?

The Sperm Aneuploidy Test (SAT) is a diagnostic test to study the genetic etiology of male infertility.
It allows for the evaluation of the presence of an abnormal number of chromosomes (aneuploidy and diploidy) in the sperm.

It analyzes the chromosomes that are frequently implicated in spontaneous miscarriages and the chromosomes that can lead to children affected with syndromes, like Down syndrome. (chromosomes 13, 18, 21, X and Y).

What is the procedure?

Why use SAT test?

Men with an abnormal SAT result conception may be impacted on three levels:

EMBRYO LEVEL

Spermatozoa with sex chromosome abnormalities or abnormalities in chromosome 13, 18, or 21 would result in an aneuploid embryo which would have a reduced potential to implant.

Diploid sperm result in triploid embryos.Rodrigo et al., 2010

PREGNANCY LEVEL:

An altered SAT result implicates a decreased pregnancy rate after ICSI and increased miscarriage rate.

Rubio et al., 2001.

OFFSPRING LEVEL:

An altered SAT result implicates an increased risk for offspring with chromosomal imbalances (For example: Down syndrome, Klinefelter syndrome or Turner’s syndrome)

Who should use SAT test?

Men with a low sperm concentration have a higher incidence of sperm chromosome abnormalities.
Couples who have suffered recurrent miscarriage of unknown etiology.
Couples who have experienced repetitive implantation failure.
Couples with a previous pregnancy having chromosomal abnormality.

Test limitations

This technique allows the detection of aneuploidy for the limited number of chromosomes included in the test.
In very few ejaculated samples or testicular samples, is there not enough spermatozoa for a proper estimation of the risk of aneuploidy.

Documentation

Specialists

Clinical Sheets

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Scientific evidence

Relevant studies:

Rodrigo L, Peinado V, Mateu E, Remohí J, Pellicer A, Simón C, Gil-Salom M, Rubio C. Impact of different patterns of sperm chromosomal abnormalities on the chromosomal constitution of preimplantation embryos. Fertil Steril. 2010 Sep; 94(4):1380-6.

Rubio C, Gil-Salom M, Simón C, Vidal F, Rodrigo L, Mínguez Y, Remohí J, Pellicer A. Incidence of sperm chromosomal abnormalities in a risk population: relationship with sperm quality and ICSI outcome. Hum Reprod. 2001 Oct; 16(10):2084-92.

Rodrigo L, Mateu E, Mercader A, Cobo A, Peinado V, Milán M, Al-Asmar N, Campos-Galindo I, García-Herrero S, Mir P, Simón C, Rubio C. New tools for embryo selection: comprehensive chromosome screening by array comparative genomic hybridization. BioMed
Research International. 2014; In Press.

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Up to 2,000 spermatozoon analyzed for each chromosome

2 independent evaluators work on every case

Results compared with internal control to assure highest reliability

Results in two weeks

Are you interested?

What is SAT test?

What is the procedure?

Why use SAT test?

Who should use SAT test?

Test limitations

Clinical Sheets

Relevant studies:

Can we help you?

Igenomix and fertility

PGT-A

ERA

EndomeTRIO

SAT Sperm Aneuploidy Test

Analysis of sperm chromosomal abnormalities.

Up to 2,000 spermatozoon analyzed for each chromosome

2 independent evaluators work on every case

Results compared with internal control to assure highest reliability

Results in two weeks

Are you interested?

What is SAT test?

What is the procedure?

Why use SAT test?

Who should use SAT test?

Test limitations

Clinical Sheets

Relevant studies:

Can we help you?

Igenomix and fertility

Other services

PGT-A

ERA

EndomeTRIO

Igenomix is in the media