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Genetic Solutions > Emma

EMMA Endometrial Microbiome Metagenomic Analysis

A screening test to evaluate the endometrium at the microbiological level

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  • Technical Overview
  • Documentation
  • Scientific evidence
  • I’m not a health specialist

20% of infertility is caused by the endometrial factor

30%
of infertile women
have pathogenic bacteria

The balance of bacteria in the endometrium is a key factor for successful implantation 

If levels of healthy bacteria are low,  pregnancy chances may be reduced 

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Overview
  • EMMA
  • Benefits
  • Indications

What is the EMMA test?

EMMA is a test that analyzes the endometrial microbiome for a better reproductive prognosis.

It indicates the endometrial microbiome balance, providing information on the proportions of healthy endometrial bacteria, including those linked to higher pregnancy rates.

What is the procedure?

implantation failure

Why use EMMA test?

  • EMMA uses the latest Next Generation Sequencing (NGS) technology to provide microbiome information in endometrial tissue by analyzing the complete endometrial microbiome profile.
  • EMMA can determine the percentage of Lactobacillus present in the endometrium, to improve the patient’s reproductive prognosis.
  • EMMA indicates the possible presence of bacterial pathogens that can cause chronic endometritis or other diseases.
  • If the endometrium is non-Lactobacillus dominated, the report will suggest the adequate treatment for each patient.
  • EMMA will determine whether the uterine microbial environment is optimal or not for embryo implantation.
  • This test can be performed in a small piece of endometrial tissue.

Who should use the EMMA test?

  • Patients with repeated implantation failure (RIF)
  • EMMA can be beneficial for any patient wishing to conceive, by assessing the microbiological environment that the embryo will encounter at implantation.

*Moreno et al., 2016

Test Limitations

  • These tests are not able to detect resistance to antibiotics. 
  • Detects the presence of pathogens associated with chronic endometritis. A negative result does not rule out the presence of other endometrial pathogens.
  • The tests are not 100% accurate at determining the bacterial species. 
Documentation
  • Specialists

Technical Sheets

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Brochure

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Scientific evidence

Relevant studies:

Evidence that the endometrial microbiota has an effect on implantation success or failure. Moreno, Inmaculada et al. American Journal of Obstetrics & Gynecology, Volume 215, Issue 6, 684 – 703.

Download

Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature 2012; 486:207–14. 

Download

Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature 2012; 486:207–14

Moreno I, Codoñer FM, Vilella F, Valbuena D, Martinez-Blanch JF, Jimenez-Almazan J, Alonso R, Alama P, Remohi J, Pellicer A, Ramon D, Simon C. Evidence that the endometrial microbiota has an effect on implantation success or failure. Am J Obstet Gynecol. 2016; 215:684-703.

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Igenomix and fertility

We work to make a world in which infertility is no longer an impossible barrier. Together with clinics and fertility doctors worldwide we investigate human reproduction to change the lives of couples who are trying to conceive.

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