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EMMA Endometrial Microbiome Metagenomic Analysis

A screening test to evaluate the endometrium at the microbiological level

Overview

EMMA
Benefits
Indications

What is the EMMA test?

EMMA is a test that analyses the endometrial microbiome to help identify abnormalities associated with a poor reproductive prognosis.
EMMA indicates the endometrial microbiome balance, providing information about the most common bacteria, including those linked to higher pregnancy rates. EMMA also includes ALICE, which detects pathogenic bacteria that can cause chronic endometritis.

What is the procedure?

EMMA can be performed on a small piece of an endometrial biopsy.

Why use EMMA test?

EMMA uses RT-PCR technology to provide endometrial microbiome information by analysing the presence and quantity of the most common bacterial pathogens of the reproductive tract.
EMMA can also determine the abundance of Lactobacillus present in the endometrium; low proportions of Lactobacillus are associated with poor reproductive outcomes.
EMMA includes the ALICE test, so it indicates the possible presence of bacteria that can cause chronic endometritis, further other pathogenic bacteria.
EMMA will determine whether the uterine microbial environment is optimal or not for embryo implantation.

Who should use the EMMA?

Patients with repeated implantation failure (RIF)
EMMA can be beneficial for any patient wishing to conceive, by assessing the microbiological environment that the embryo will encounter at implantation

*Moreno et al., 2016

Test limitations:

These tests are not able to detect resistance to antibiotics
A negative result doesn’t rule out the presence of other endometrial pathogens

Manual

Download

Documentation

EMMA Specialists' documents

Brochure

Download

EMMA Manual

Download

Antibiotic Dosage Recommendations

Download

Acceptable OCPs for EMMA and ALICE Testing

Download

Scientific evidence

Relevant related studies:

Endometrial microbiota composition is associated with reproductive outcome in infertile patients

Inmaculada Moreno, Iolanda Garcia-Grau, David Perez-Villaroya, Marta Gonzalez-Monfort, Mustafa Bahçeci, Marcelo J. Barrionuevo, Sagiri Taguchi, Elena Puente, Michael Dimattina, Mei Wei Lim, Georgina Meneghini, Mira Aubuchon, Mark Leondires, Alexandra Izquierdo, Martina Perez-Olgiati, Alejandro Chavez, Ken Seethram, Davide Bau, Carlos Gomez, Diana Valbuena, Felipe Vilella & Carlos Simon

January 04, 2022

Evidence that the endometrial microbiota has an effect on implantation success or failure.

Moreno, Inmaculada et al. American Journal of Obstetrics & Gynecology, Volume 215, Issue 6, 684 – 703.

Am J Obstet Gynecol. 2016 Dec;215(6):684-703. doi: 10.1016/j.ajog.2016.09.075. Epub 2016 Oct 4.

Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature 2012; 486:207–14.

Igenomix and fertility

We work to make a world in which infertility is no longer an impossible barrier. Together with clinics and fertility doctors worldwide we investigate human reproduction to change the lives of couples who are trying to conceive.

Other services

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EndomeTRIO

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ALICE

Detects the bacteria causing chronic endometritis

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EMMA Endometrial Microbiome Metagenomic Analysis

A screening test to evaluate the endometrium at the microbiological level

20% of infertility is caused by the endometrial factor

30% of infertile women have pathogenic bacteria

Are you interested?

What is the EMMA test?

What is the procedure?

Why use EMMA test?

Who should use the EMMA?

Test limitations:

Manual

Brochure

EMMA Manual

Antibiotic Dosage Recommendations

Acceptable OCPs for EMMA and ALICE Testing

Relevant related studies:

Can we help you?

Igenomix and fertility

ERA

EndomeTRIO

ALICE