EMMA Endometrial Microbiome Metagenomic Analysis

A screening test to evaluate the endometrium at the microbiological level

Overview

EMMA
Benefits
Indications

What is the EMMA test?

EMMA is a test that analyses the endometrial microbiome to help identify abnormalities associated with a poor reproductive prognosis.
EMMA indicates the endometrial microbiome balance, providing information on the proportions of all endometrial bacteria, including those linked to higher pregnancy rates. EMMA also includes ALICE, which detects pathogenic bacteria that can cause chronic endometritis.

What is the procedure?

EMMA can be performed on a small piece of an endometrial biopsy.

Why use EMMA test?

EMMA uses the latest Next Generation Sequencing (NGS) technology to provide endometrial microbiome information by analysing the complete profile of the bacteria present in the tissue
EMMA can determine the percentage of Lactobacillus present in the endometrium; low proportions of Lactobacillus are associated with poor reproductive outcomes
EMMA includes the ALICE test, so it indicates the possible presence of bacteria that can cause chronic endometritis, further other pathogenic bacteria.
If the endometrium is non-Lactobacillus dominated, the report will suggest the adequate treatment for each patient
EMMA will determine whether the uterine microbial environment is optimal or not for embryo implantation

Who should use the EMMA?

Patients with repeated implantation failure (RIF)
EMMA can be beneficial for any patient wishing to conceive, by assessing the microbiological environment that the embryo will encounter at implantation

*Moreno et al., 2016

Test limitations:

These tests are not able to detect resistance to antibiotics
The tests are not 100% accurate at determining the bacterial species.
A negative result doesn’t rule out the presence of other endometrial pathogens

Documentation

EMMA Specialists' documents

Relevant related studies:

Evidence that the endometrial microbiota has an effect on implantation success or failure. Moreno, Inmaculada et al. American Journal of Obstetrics & Gynecology, Volume 215, Issue 6, 684 – 703.

Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature 2012; 486:207–14.

Igenomix and fertility

We work to make a world in which infertility is no longer an impossible barrier. Together with clinics and fertility doctors worldwide we investigate human reproduction to change the lives of couples who are trying to conceive.

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EMMA Endometrial Microbiome Metagenomic Analysis

A screening test to evaluate the endometrium at the microbiological level

20% of infertility is caused by the endometrial factor

30% of infertile women have pathogenic bacteria

Are you interested?

What is the EMMA test?

What is the procedure?

Why use EMMA test?

Who should use the EMMA?

Test limitations:

Clinical Sheets

Brochure

EndomeTRIO manual

Relevant related studies:

Can we help you?

Igenomix and fertility

ERA

EndomeTRIO

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ALICE

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