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Genetic Solutions > Family Balancing

Family Balancing

PGT-A helps your patients select the desired sex of their embryos

  • Technical Overview
  • Documentation
  • Scientific evidence
  • I’m not a health specialist

160k embryos analyzed/year 

98% accuracy

Proprietary artificial intelligence algorithm 

12k IVF cycles/year

Are you interested?

Request information Or email us at infousa@igenomix.com
Overview
  • Family Balancing
  • Benefits
  • Indications

What is Family Balancing?

  • Family balancing test is used alongside in-vitro fertilization (IVF) to screen abnormalities in embryos.
  • The information obtained also helps us to select the sex of the embryo prior to transfer.

What is the procedure?

Why Family Balancing?

  • NGS (Next-Generation Sequencing): Our technology and experience allow the analysis of 24 chromosomes, in a 12-hour procedure which provides results in more than 99% of cases.
  • Increases pregnancy rates per transfer: Selecting chromosomally normal embryos can increase the rate of pregnancy after transfer. 
  • Reduces miscarriage risk: In the general population, 25% of all clinical pregnancies end in miscarriage. The risk for miscarriage is reduced if an euploid embryo is transferred.  
  • Increases the likelihood of having a healthy baby: Some pregnancies with aneuploidies can result in babies affected with chromosomal syndromes. 
  • Reduces time and necessary resources: The time and resources necessary to achieve a pregnancy are reduced. 
  • Reduces risk of multiple pregnancy: Patient can utilized a single embryo transfer of a euploid embryo rather than transferring multiple untested embryos to reduce the risk of multiple pregnancy.  

Who should use Family Balancing test?

  • For couples that wish to know the gender of their baby
  • Female patients over age 35
  • Patients interested in selecting the best embryo for an elective Single Embryo Transfer or SET and avoid multiple pregnancies
  • Patients who already have a child with a chromosomal abnormality or had a previous pregnancy with a chromosomal abnormality issue
Documentation
  • Specialists

Clinical Sheets

Download

Brochure

Download
Scientific evidence

PGT-A Relevant Studies

  • Igenomix
  • External

Rubio et al: In vitro fertilization with preimplantation genetic diagnosis for aneuploidies in advanced maternal age: a randomized, controlled study. Fertil Steril. 2017 May;107(5):1122-1129. 

Yang Z, Liu J, Collins GS, Salem SA, Liu X, Lyle SS, et al. Selection of single blastocysts for fresh transfer via standard morphology assessment alone and with array CGH for good prognosis IVF patients: results from a randomized pilot study. Mol Cytogenet 2012 May 2; 5(1):24.  

Coates A, Kung A, Mounts E, Hesla J, Bankowski B, Barbieri E, Ata B, Cohen J, Munné S. Optimal euploid embryo transfer strategy, fresh versus frozen, after Preimplantation Genetic Testing for Aneuploidies with next generation sequencing: a randomized controlled trial.  Fertil Steril. 2017 Mar;107(3):723-730.e3.   

Coates A, Bankowski BJ, Kung A, Griffin DK, Munne S. Differences in pregnancy outcomes in donor egg frozen embryo transfer (FET) cycles following Preimplantation Genetic Testing for Aneuploidies (PGT-A): a single center retrospective study. J Assist Reprod Genet. 2017 Jan;34(1):71-78.    

Sanchez-Ribas et al., Transcriptomic behavior of genes associated with chromo some 21 aneuploidies in early embryo development. Fertility and Sterility, 2019; 111, 5:991-1001. 

Goldwaser, Tamar et al. Cell-free DNA for the detection of fetal aneuploidy. Fertility and Sterility, 2018; 109, 2, 195 – 200. 

Kuznyetsov V, Madjunkova S, Antes R, Abramov R, Motamedi G, Ibarrientos Z, et al.  Evaluation of a novel non-invasive preimplantation genetic screening approach. PLoS ONE; 2018; 13(5): e0197262. 

Munné S, Status of preimplantation genetic testing and embryo selection. RBMO. 2018; 37(4):393-396. 

Levy et al., Prenatal diagnosis by chromosomal microarray analysis. Fertility and Sterility, 2017; 109, 2, 201–212.  

Ottolini C. et al., Scientific Reports. Tripolar mitosis and partitioning of the genome arrests human preimplantation development in vitro, 2017;7:9744. 

Ottolini C. et al., Scientific Reports. Tripolar mitosis and partitioning of the genome arrests human preimplantation development in vitro, 2017;7:9744. 

Munné, Santiago et al. Mosaicism: “survival of the fittest” versus “no embryo left behind”. Fertility and Sterility, 2016; 105, 5, 1146 – 1149. 

Bolton et al., Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential. Nature Communications, 2016; 29;7:11165. 

Cimadomo D. et al, The Impact of Biopsy on Human Embryo Developmental Potential during Preimplantation Genetic Diagnosis. Hindawi, 2016, 7193075. 

Scott RT, Galliano D., The challenge of embryonic mosaicism in preimplantation genetic screening. Fertility and Sterility, 2016; 105, 5. 

McCoy RC, Demko ZP, Ryan A, Banjevic M, Hill M, Sigurjonsson S, et al.  Evidence of Selection against Complex Mitotic-Origin Aneuploidy during Preimplantation Development. PLoS Genet, 2015; 11 (10): e1005601.  

Kung A. et al., Validation of next-generation sequencing for comprehensive chromosome screening of embryos. Reproductive BioMedicine, 2015; 1472-6483. 

Greco E, Minasi MG, Fiorentino F. Healthy Babies after Intrauterine Transfer of Mosaic Aneuploid Blastocysts, N Engl J Med, 2015; Nov 19;373(21):2089-90.  

Yang Z et al., Selection of single blastocysts for fresh transfer via standard morphology assessment alone and with array CGH for good prognosis IVF patients: results from a randomized pilot study., 2012, 5:24. 

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We work to make a world in which infertility is no longer an impossible barrier. Together with clinics and fertility doctors worldwide we investigate human reproduction to change the lives of couples who are trying to conceive.

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