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Genetic Solutions > Emma

EMMA Endometrial Microbiome Metagenomic Analysis

A screening test to evaluate the endometrium at the microbiological level

  • Technical Overview
  • Documentation
  • Scientific evidence
  • I’m not a health specialist

30% of infertile women have pathogenic bacteria detected in their endometrium

Upgraded EMMA panel: the most precise panel available, developed after analysing over 70,000 clinical samples during the last 5 years

The upgraded EMMA panel now identifies bacteria at the species level, enabling more precise and targeted treatments

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Overview
  • EMMA
  • Benefits
  • Indications

What is the EMMA (Endometrial Microbiome Metagenomic Analysis) test?

  • EMMA is a test that analyses the endometrial microbiome to help identify abnormalities associated with a poor reproductive prognosis.
  • EMMA indicates the endometrial microbiome balance, providing information about the most common bacteria, including those linked to higher pregnancy rates. EMMA also includes ALICE, which detects pathogenic bacteria that can cause chronic endometritis.
  • Igenomix has analyzed over 70,000 clinical samples during the last 5 years.
  • Through our experience with the EMMA & ALICE tests, we have identified the bacterial pathogens most frequently detected in the endometrium.
  • Based on this data, we have developed the most comprehensive and precise panel, encompassing all clinically relevant bacteria, with most identified at the species level, enabling a more precise and targeted treatments.

What is the procedure?

implantation failure
  • EMMA can be performed on a small piece of an endometrial biopsy.

Why use EMMA test?

  • EMMA uses RT-PCR technology to provide endometrial microbiome information by analysing the presence and quantity of the most common bacterial pathogens of the reproductive tract.
  • EMMA can also determine the abundance of Lactobacillus present in the endometrium; low proportions of Lactobacillus are associated with poor reproductive outcomes.
  • EMMA includes the ALICE test, so it indicates the possible presence of bacteria that can cause chronic endometritis, further other pathogenic bacteria.
  • EMMA will determine whether the uterine microbial environment is optimal or not for embryo implantation.
  • If the endometrial microbial environment is not optimal for embryo implantation, a recommendation for a precise and targeted treatment is provided.

Who should use the EMMA?

  • Patients with repeated implantation failure (RIF)
  • Patients with repeated pregnancy loss (RPL)

*Moreno et al., 2016, Moreno 2022, Iwami 2023

Test limitations:

  • These tests are not able to detect resistance to antibiotics
  • A negative result doesn’t rule out the presence of other endometrial pathogens

Manual

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Documentation
  • EMMA Specialists' documents

Brochure

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EMMA Manual

Download

EndomeTRIO Manual

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Acceptable OCPs for EMMA and ALICE Testing

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Upgraded
EMMA & Alice

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Scientific evidence

Relevant related studies:

Endometrial microbiota composition is associated with reproductive outcome in infertile patients

Inmaculada Moreno, Iolanda Garcia-Grau,  David Perez-Villaroya,  Marta Gonzalez-Monfort,  Mustafa Bahçeci, Marcelo J. Barrionuevo, Sagiri Taguchi,  Elena Puente,  Michael Dimattina, Mei Wei Lim, Georgina Meneghini, Mira Aubuchon, Mark Leondires, Alexandra Izquierdo, Martina Perez-Olgiati, Alejandro Chavez, Ken Seethram, Davide Bau, Carlos Gomez, Diana Valbuena, Felipe Vilella & Carlos Simon

January 04, 2022

Evidence that the endometrial microbiota has an effect on implantation success or failure.

Moreno, Inmaculada et al.
 American Journal of Obstetrics & Gynecology, Volume 215, Issue 6, 684 – 703.

Am J Obstet Gynecol. 2016 Dec;215(6):684-703. doi: 10.1016/j.ajog.2016.09.075. Epub 2016 Oct 4.

Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature 2012; 486:207–14. 

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Igenomix and fertility

We work to make a world in which infertility is no longer an impossible barrier. Together with clinics and fertility doctors worldwide we investigate human reproduction to change the lives of couples who are trying to conceive.

Other services

ERA

Evaluates the endometrial receptivity

More information

EndomeTRIO

A new dimension of endometrial health to improve your reproductive prognosis More information

ALICE

Detects the bacteria causing chronic endometritis

More information

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Igenomix is not affiliated with any news outlet or publication identified above. News coverage does not constitute an endorsement of Igenomix or its products.

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