- To enhance the genetic testing of IVF embryos and expand the diagnostic capabilities and clinical utility of our preimplantation genetic testing for aneuploidy (Smart PGT-A), we have developed and validated a parallel targeted Next-Generation Sequencing (NGS) strategy using the power of SNP technology with out the need for parental samples.
- Single Nucleotide Polymorphisms (SNPs) are changes in single nucleotides distributed throughout the genome and frequently vary at the same genomic position between individuals. Most SNPs have only two different alleles.
- SNPs can be used for ‘DNA finger printing’ to detect ploidy differences, DNA contamination and the genetic relatedness of embryos.
- This dual assessment serves as a complementary test for the detection of the chromosome abnormalities not detected with our current approach, significantly enhancing the accuracy and confidence of the Smart PGT-A test.
What is Smart PGT-A Plus?
- Building upon our expertise, our latest offering, Smart PGT-A Plus, is a 4-in-1 genetic test which combines our extensively validated in-house Next Generation Sequencing (NGS) technology with an additional and validated targeted Next Generation Sequencing (NGS) strategy using the power of SNPs (Single Nucleotide Polymorphism) without the need for parental samples.
- This advanced screening solution goes beyond Smart PGT-A by incorporating additional features including ploidy analysis (complete chromosomes sets), sibling embryo genetic relatedness and DNA contamination detection into a standard PGT-A workflow significantly increasing accuracy and confidence in selecting the optimal embryo for transfer.
Smart PGT-A Plus
Our most advanced 4-in-1 genetic test solution
Smart PGT- A
Our custom and validated technology that combines next-generation sequencing (NGS) with advanced algorithms and machine learning, enabling the analysis of genomic data from embryos with exceptional accuracy and reliability.
Genetic PN Check | Ploidy Detection
Smart PGT-A Plus enables the detection of both haploidy and triploidy. This crucial assessment ensures the selection of embryos with the correct chromosomal content, minimizing the risk of genetic abnormalities. Smart PGT-A Plus also increases the number of viable euploid embryos available for transfer by detecting true 2PN (diploid) embryos from among morphologically identified 0, 1 and 2.1/3PN embryos.
Siblings QC | DNA Fingerprinting Siblings
Our quality control process includes Siblings QC, where we employ DNA fingerprinting techniques. This ensures accurate identification, differentiation and the assurance that the tested embryo is genetically related to the others in the patient’s cohort reducing the risk of sample mix-ups due to human error.
Detection of DNA Contamination
We have implemented measures to identify and detect both external cell/DNA and maternal cell contamination increasing the accuracy and confidence of the testing process significantly reducing the risk of misdiagnosis.
Smart PGT-A & Smart PGT-A Plus Compared
What makes our Smart PGT-A Plus stand out from the rest?
Offers enhanced confidence with robust and accurate results, utilizing two independent analyses to detect abnormalities.
Increases the number of viable embryos available for transfer.
Strengthened by the power of big data and artificial intelligence, effectively overcoming the limitations of human subjectivity and greatly reducing the risk of human error.
Enhances accuracy and reduces the risk of misdiagnosis by detecting external and maternal cell DNA contamination.
Maximizes the likelihood of successful pregnancy by carefully identifying optimal embryos for transfer.
Provides confirmation that all embryos from the same patient are genetically related to each other without the need for additional parental samples.
Reduces the risk of miscarriage due to previously undetected abnormalities (e.g. triploidy).
Ensures enhanced quality control in the laboratory procedures conducted within your IVF lab, providing greater assurance.
While any couple can have an embryo with aneuploidy, the chances can increase with the following factors:
Female age over 35
History of recurrent pregnancy loss
Previous IVF failure
Prior child or pregnancy with a chromosome abnormality
Rescue embryos following abnormal fertilization (0PN, 1PN, 2.1PN/3PN)
Reproductive history of triploidy/haploidy
Complete or partial molar pregnancy
- Sibling relatedness analysis can only be performed for cohorts of 2 or more diploid embryos. Cannot be reported for chaotic, haploid or triploid embryos, or when ploidy analysis is non-informative.
- The origin of contamination cannot be determined when an admixture of contamination is detected.
- The origin of the sample cannot be determined when a sibling mismatch is detected. Possibilities include:
- Complete exogenous contamination.
- DNA from an unexpected embryo.
- Biological diversity.
- Smart PGT-A Plus cannot confirm that the correct embryo was transferred.