A study carried out by an independent research team on a group of 281 Chinese women suffering from recurring implantation failure has determined that personalized embryo transfer guided by the ERA test doubles the pregnancy rate in patients with previous implantation failure.
Although it is generally estimated that the endometrium becomes receptive after 120 hours of exposure to progesterone, previous studies have shown that around 30% of patients with recurring implantation failure have a displaced window of implantation; in other words, they need more or less than those 120 hours to become receptive. The ERA (Endometrial Receptivity Analysis) test developed by Igenomix informs us when the endometrium is receptive and when to carry out a personalized embryo transfer.
This study proves the effectiveness of the ERA test in patients with implantation failure. “Controlling this moment and transferring the embryo on a specific day and at a specific time has led to a significant improvement in reproductive results” explains Professor Carlos Simón, one of the test developers.
The ERA test achieved a 50% clinical pregnancy rate
In order to test the impact of carrying out a personalized transfer in patients with implantation failure, the research team concluded that 35% of the samples collected through endometrial biopsy were receptive while 65% were not.
The group of patients who underwent the ERA test (140/281), in which a personalized embryo transfer was carried out when the endometrium was receptive, obtained a 50% clinical pregnancy rate (70/140), while the group guided by a standard transfer obtained a much lower pregnancy rate, namely 24.8% (35/141). Thus, the results show a 25% increase in the pregnancy rate following the personalized implantation window study with the ERA test.
“Since we developed the ERA test to solve cases in which the patient’s implantation window was displaced, one of our goals as experts in the study of the endometrium was to always discover when this event occurred. This study carried out in patients who have been unable to reproduce due to implantation failure provides evidence that the endometrium could be one of the biggest problems”, concludes Professor Simón.