In order for the endometrium to be in the best condition for the implantation of the embryo, and for pregnancy to develop, a series of conditions must be met.
Apart from embryo itself, an important factor is the microbial environment present in the woman’s uterus, such as the absence of infections like endometritis or that the transfer is performed when the implantation window is at the ideal moment.
What are the main characteristics of a perfect endometrium for implantation
In order for the embryo to be able to implant, certain premises must be fulfilled, which we will tell you about below:
The endometrium must be receptive to receive the embryo and for implantation to take place. The embryo, for its part, must have the correct number of chromosomes, what we call a euploid embryo.
In addition, another factor that must be taken into account for embryo implantation to take place is the state of the microbiota or microbial environment. The endometrial flora is crucial in the reproductive process, especially when we find the presence of pathogens that can cause chronic endometritis.
What is chronic endometritis and why can it cause a difficult pregnancy?
Chronic endometritis is an infection that affects the microbiota of the endometrium.
It is caused by inflammation in the endometrium itself due to the presence of pathogenic bacteria.
The main difficulty of chronic endometritis is in its detection. It can be asymptomatic and does not usually cause discomfort or serious health problems, unless the affected woman wants to become pregnant, since in some cases it can cause infertility.
According to studies carried out by Igenomix, it is estimated that about 30% of women who undergo assisted reproduction treatment may have chronic endometritis.
EndomeTRIO: a complete view of your endometrial health to help you in your reproductive journey
Igenomix has developed two complementary tests to determine the best time for the endometrium to be at the perfect moment for embryo implantation: EMMA and ALICE, which analyze the endometrial flora and detect possible pathogens causing chronic endometritis, respectively.
The EMMA test helps to determine the overall composition of all the bacteria in the uterine cavity, while the ALICE test focuses on those specific bacteria that we know are the most frequent causes of chronic endometritis and helps to diagnos a disease that many patients do not even suspect they may have.
In addition, together with the ERA test, we can determine the implantation window of each patient and thus personalize the embryo transfer at the exact moment, increasing the probabilities of achieving pregnancy.